The Mark Twain Readers Award, or simply Mark Twain Award, is a children's book award which annually recognizes one book selected by vote of Missouri schoolchildren from a list prepared by librarians and volunteer readers. It is now one of four Missouri Association of School Librarians (MASL) Readers Awards and is associated with school grades 4 to 6; the other MASL Readers Awards were inaugurated from 1995 to 2009 and are associated with grades K–3, 6–8, 9–12 and nonfiction. The 1970 Newbery Medal winning book Sounder, by William H. Armstrong, was the inaugural winner of the Mark Twain Award in 1972.

Peg Kehret has won the Mark Twain Award four times, once in 1999 for Small Steps: The Year I Got Polio, a memoir of her childhood, and three times in six years from 2007 to 2012 for novels.